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In Philadelphia, a battle between local officials and the Trump administration is heating up.

In defiance of threats from the Justice Department, public health advocates in Philadelphia have launched a nonprofit to run a facility to allow people to use illegal drugs under medical supervision. It is the most concrete step yet the city has taken toward eventually opening a so-called supervised injection site.

The non-profit, called Safehouse, was formed after a political heavyweight, former Pennsylvania governor, Ed Rendell, joined the board.

Updated at 10:50 p.m. ET

New York State Police have arrested the son of the owner of Prestige Limousine Chauffeur Service, the company involved in the crash that left 20 people dead about 40 miles outside Albany last weekend. Nauman Hussain, whom police described as the company's "operator," was charged Wednesday with criminally negligent homicide for his role in the fatal incident.

More than a week has passed since Saudi writer Jamal Khashoggi vanished after visiting the Saudi Arabian consulate in Istanbul. Turkish authorities are telling journalists what they think happened, citing released video footage: that Khashoggi was targeted and murdered.

President Trump said Wednesday that he has spoken to the Saudi government "at the highest levels" about the situation.

Updated at 4:55 p.m. ET

The Justice Department unsealed charges Wednesday against a suspected Chinese spy for allegedly conducting economic espionage and trying to steal trade secrets from U.S. aerospace companies.

The alleged Chinese intelligence officer, Yanjun Xu, was extradited to the United States on Tuesday from Belgium, where he was arrested in April at Washington's request.

His extradition marks what appears to be the first time that a Chinese spy has been brought to the U.S. to face prosecution, according to U.S. officials.

USA Today published an opinion column by President Trump Wednesday in which the president falsely accused Democrats of trying to "eviscerate" Medicare, while defending his own record of protecting health care coverage for seniors and others.

The column — published just weeks ahead of the midterm elections — underscores the political power of health care to energize voters. But it makes a number of unsubstantiated claims.

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